California Encephalitis Antibody, IgG by IFA, Serum (INACTIVE as of 10/30/14: See Ordering Recommendations)
0050508
Ordering Recommendation
No alternative testing available in the U.S. See Inactivation Notification.
Mnemonic
CALIF
Methodology
Semi-Quantitative Indirect Fluorescent Antibody
Performed
Tue, Fri
Reported
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.05 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Please mark specimens plainly as "acute" or "convalescent."  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Contaminated, hemolyzed, severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Less than 1:16  
Interpretive Data
A positive result for IgG may suggest current or past infection.La Crosse virus is related to viruses within the California Encephalitis Group and, generally, is reactive with antibody to other viruses within this group.  
Note
Serum specimens drawn within the first two weeks after onset are variably negative for IgG antibody and should not be used to exclude the diagnosis of arboviral disease.  Seroconversion between acute and convalescent sera is considered strong evidence of recent infection.  The best evidence for infection is a significant change (fourfold difference in titer) on two appropriately timed specimens, where both tests are done in the same laboratory at the same time.
CPT Code(s)
86651
Components
Component Test Code*Component Chart Name
0050508Calif Encephalitis Antibody IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • California Encephalitis Antibody, IgG Serum
  • Encephalitis Antibody
  • Encephalitis, La Crosse