Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM by ELISA, CSF
0050408
 
Ordering Recommendation
Mnemonic
HSVMCCSF
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory.
Specimen Required
Patient Preparation
 
Collect
CSF.  
Specimen Preparation
Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.2 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Specimen types other than CSF. Contaminated or heat-inactivated specimens.  
Remarks
Indicate source on test request form.  
Stability
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
0.89 IV or less: Negative - No significant level of detectable HSV IgM antibody.
0.90-1.09 IV: Equivocal - Questionable presence of IgM antibodies. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive - IgM antibody to HSV detected, which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
Interpretive Data
The detection of antibodies to herpes simplex virus in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer or serum antibodies across the blood-brain barrier.

Fourfold or greater rise in CSF antibodies to herpes on specimens at least 4 weeks apart are found in 74-94% of patients with herpes encephalitis. Specificity of the test based on a single CSF testing is not established. Presently PCR is the primary means of establishing a diagnosis of herpes encephalitis.

See Compliance Statement B: www.aruplab.com/CS
Note
CPT Code(s)
86694
Components
Component Test Code*Component Chart Name
0050408HSV 1 and/or 2 Antibodies IgM, CSF
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • HSV
  • HSV antibodies
  • HSV IgM and IgG