Not recommended for herpes simplex virus (HSV) testing; IgM lacks adequate predictive value for acute infection. Molecular testing is preferred (refer to Herpes Simplex Virus by PCR (0060041)).
- Patient Preparation
- Specimen Preparation
- Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.2 mL)
- Storage/Transport Temperature
- Unacceptable Conditions
- Specimen types other than CSF. Contaminated or heat-inactivated specimens.
- Indicate source on test request form.
- Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year
0.90-1.09 IV: Equivocal - Questionable presence of IgM antibodies. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive - IgM antibody to HSV detected, which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
Fourfold or greater rise in CSF antibodies to herpes on specimens at least 4 weeks apart are found in 74-94% of patients with herpes encephalitis. Specificity of the test based on a single CSF testing is not established. Presently PCR is the primary means of establishing a diagnosis of herpes encephalitis.
|Component Test Code*||Component Chart Name||LOINC|
|0050408||HSV 1 and/or 2 Antibodies IgM, CSF||63432-9|
- HSV antibodies
- HSV IgM