Rickettsia typhi (Typhus Fever) Antibody, IgG by IFA
Ordering Recommendation

Confirm presence of Rickettsia typhi. Panel test (IgG and IgM) is preferred. Requires comparison of acute- to convalescent-phase serology.

Semi-Quantitative Indirect Fluorescent Antibody
Tue, Fri
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.05 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as acute or convalescent. 
Storage/Transport Temperature
Unacceptable Conditions
Contaminated, hemolyzed, or severely lipemic specimens. 
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
< 1:64  Negative - No significant level of Rickettsia typhi IgG antibody detected.
1:64-1:128  Equivocal - Questionable presence of Rickettsia typhi IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
≥ 1:256  Positive - Presence of IgG antibody to Rickettsia typhi detected, suggestive of current or past infection.
Interpretive Data
This test is for antibodies to Rickettsia typhi. Any antibody reactivity to Rickettsia typhi antigen should, however, also be considered group-reactive for the Typhus Fever group (Rickettsia prowazekii). Seroconversion between acute and convalescent sera is considered strong evidence of recent infection. The best evidence for infection is a significant change (fourfold difference in titer) on two appropriately timed specimens, where both tests are done in the same laboratory at the same time.

Component Test Code*Component Chart NameLOINC
0050381Typhus Fever Antibody, IgG5324-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Murine Typhus Antibodies, IgG
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  • Typhus Fever Group IgG Antibody