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Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG & IgM (CSF) with Reflex to Type 1 & 2 Glycoprotein G-Specific Ab, IgG
0050364
Ordering Recommendation

Not recommended for herpes simplex virus (HSV) testing; lacks adequate predictive value for acute infection. Preferred testing is HSV PCR (0060041).

Mnemonic
HERPRCSF
Methodology
Semi-Quantitative Chemiluminescent Immunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
CSF.  
Specimen Preparation
Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Specimen types other than CSF. Contaminated or heat-inactivated specimens.  
Remarks
 
Stability
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
Test Number
Components
Reference Interval
 HERPES I/II IgM0.89 IV or less; Negative - No significant level of detectable HSV IgM antibody.
0.90-1.09 IV; Equivocal - Questionable presence of IgM antibodies.  Repeat testing in 10-14 days may be helpful.
1.10 IV or greater; Positive - IgM antibody to HSV detected which may indicate a current or recent infection.  However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
 HERPES I/II IgG0.89 IV or less: Negative - No significant level of detectable HSV IgG antibody.
0.90-1.09 IV: Equivocal - Questionable presence of IgG antibodies. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive - IgG antibody to HSV detected which may indicate a current or past HSV infection.
0050379Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.10 IV: Equivocal - Questionable presence of IgG antibody to HSV type 1.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past infection.
0050359Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
0.90-1.10 IV: Equivocal - Questionable presence of IgG antibody to HSV type 2.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or past HSV infection.

Interpretive Data


Compliance Statement E: The manufacturer has not determined the efficacy of this test when performed on CSF specimens. The performance characteristics of this test were determined by ARUP laboratories.
Note
If HSV 1/2 IgG, CSF is greater than or equal to 1.10 IV , then HSV 1 gG-Specific IgG, CSF and HSV 2 gG-Specific IgG, CSF will be added. Additional charges apply.
CPT Code(s)
86694 and 86694; if reflexed, add 86695 and 86696
Components
Component Test Code*Component Chart NameLOINC
0050394HSV 1/2 Antibody Screen IgG, CSF13249-8
0050408HSV 1 and/or 2 Antibodies IgM, CSF63432-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • glycoprotein type-specific reactivity
  • Herpes Simplex Antibodies, IgG IgM CSF
  • Herpes Simplex CSF
  • HSV 1, 2 IgG IgM CSF
  • HSV 1,2
  • HSV 1,2 and glycoprotein reflex
  • HSV 1,2 glycoprotein CSF
  • HSV CSF antibody
  • HSV glycoprotein G CSF
  • HSV glycoprotein G-based type-specific CSF