Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG & IgM (CSF) with Reflex to Type 1 & 2 Glycoprotein G-Specific Ab, IgG
Ordering Recommendation
Not recommended for herpes simplex virus (HSV) testing; lacks adequate predictive value for acute infection. Preferred testing is Herpes Simplex Virus (HSV-1/HSV-2) Subtype by PCR (2010095).
New York DOH Approval Status
Specimen Required
CSF.
Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Specimen types other than CSF. Contaminated, heat-inactivated, or hemolyzed specimens.
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year
Methodology
Semi-Quantitative Chemiluminescent Immunoassay /Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
HSV 1 and/or 2 Antibodies IgM, CSF | 0.89 IV or less | |
HSV 1/2 Antibody Screen IgG, CSF | 0.89 IV or less |
Interpretive Data
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Component |
Interpretation |
---|---|
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM, CSF by ELISA | 0.89 IV or less; Negative. No significant level of detectable HSV IgM antibody. 0.90-1.09 IV: Equivocal. Questionable presence of IgM antibodies. Repeat testing in 10-14 days may be helpful. 1.10 IV or greater: Positive. IgM antibody to HSV detected which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post infection. |
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF | 0.89 IV or less: Negative - No significant level of detectable HSV IgG antibody. 0.90-1.09 IV: Equivocal - Questionable presence of IgG antibodies. Repeat testing in 10-14 days may be helpful. 1.10 IV or greater: Positive - IgG antibody to HSV detected which may indicate a current or past HSV infection. |
Laboratory Developed Test (LDT)
Note
If HSV 1/2 IgG, CSF is greater than or equal to 1.10 IV , then HSV 1 gG-Specific IgG, CSF and HSV 2 gG-Specific IgG, CSF will be added. Additional charges apply.
Hotline History
CPT Codes
86694 x2; if reflexed, add 86695; 86696
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050394 | HSV 1/2 Antibody Screen IgG, CSF | 13249-8 |
0050408 | HSV 1 and/or 2 Antibodies IgM, CSF | 63432-9 |
Aliases
- glycoprotein type-specific reactivity
- Herpes Simplex Antibodies, IgG IgM CSF
- Herpes Simplex CSF
- HSV 1, 2 IgG IgM CSF
- HSV 1,2
- HSV 1,2 and glycoprotein reflex
- HSV 1,2 glycoprotein CSF
- HSV CSF antibody
- HSV glycoprotein G CSF
- HSV glycoprotein G-based type-specific CSF