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Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG and IgM
0050291
Ordering Recommendation

Not recommended for herpes simplex virus (HSV) testing; IgM lacks adequate predictive value for acute infection. If pursuing antibody testing, preferred test is HSV IgG glycoprotein antibodies (0051152). If acute HSV infection is suspected, molecular testing is preferred (0060041).

Mnemonic
HERP PAN
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Chemiluminescent Immunoassay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. 
Specimen Preparation
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent." 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Refer to individual components. 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Test Number
Components
Reference Interval
0050293Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG
0.89 IV or less:Not Detected.
0.90-1.09 IV:Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater:Detected.

0050641Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM by ELISA
0.89 IV or less:Not Detected.
0.90-1.09 IV:Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater:Detected - IgM antibody to HSV detected, which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.



Interpretive Data


Note
CPT Code(s)
86694 x2
Components
Component Test Code*Component Chart NameLOINC
0050286HSV Type 1/2 Combined Ab, IgG27948-9
0050641HSV 1 and/or 2 Abs, IgM by ELISA41399-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HSV 1 and 2
  • HSV 1 and 2 antibody panel
  • HSV 1, 2
  • HSV 1, 2, IgG IgM