Ordering Recommendation

Order to document past Epstein-Barr virus (EBV) exposure or, in conjunction with other serologic tests, diagnose primary EBV infectious mononucleosis.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated or grossly hemolyzed specimens.

Remarks

Label specimens plainly as ''acute'' or ''convalescent.''

Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Methodology

Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

1-2 days

Reference Interval

Effective February 19, 2013

17.9 U/mL or less: Not Detected
18.0-21.9 U/mL: Indeterminate.  Repeat testing in 10-14 days may be helpful.
22.0 U/mL or greater: Detected

Interpretive Data



Compliance Category

FDA

Note

EBNA values obtained with different manufacturers' assay methods may not be used interchangeably.  The magnitude of the reported EBNA level cannot be correlated to an endpoint titer.

Hotline History

N/A

CPT Codes

86664

Components

Component Test Code* Component Chart Name LOINC
0050245 EBV Antibody to Nuclear Antigen IgG 30083-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • EBNA Antibody
  • EBNA-IgG Ab
  • EBV Antibodies
  • EBV Antibody to Nuclear Antigen
  • EBV Nuclear Antibody
Epstein-Barr Virus Antibody to Nuclear Antigen, IgG