West Nile Virus Antibody, IgG by ELISA, CSF
0050238
 
Ordering Recommendation
Mnemonic
WNIL IGG
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue, Fri
Reported
1-5 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory.
Specimen Required
Patient Preparation
 
Collect
CSF.  
Specimen Preparation
Transfer 2 mL CSF to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Contaminated, heat-inactivated, or hemolyzed specimens.  
Remarks
 
Stability
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
1.29 IV or less: Negative - No significant level of West Nile virus IgG antibody detected.
1.30-1.49 IV: Equivocal - Questionable presence of West Nile virus IgG antibody detected. Repeat testing in 10-14 days may be helpful.
1.50 IV or greater: Positive - Presence of IgG antibody to West Nile virus detected, suggestive of current or past infection.
Interpretive Data
This test is intended to be used as a semi-quantitative means of detecting West Nile virus-specific IgG in CSF specimens in which there is a clinical suspicion of West Nile virus infection. This test should not be used solely for quantitative purposes, nor should the results be used without correlation to clinical history or other data. Because other members of the Flaviviridae family, such as St. Louis encephalitis virus, show extensive cross-reactivity with West Nile virus, serologic testing specific for these species should be considered.

The detection of antibodies to West Nile virus in cerebrospinal fluid may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.

See Compliance Statement B: www.aruplab.com/CS
Note
CPT Code(s)
86789
Components
Component Test Code*Component Chart Name
0050238West Nile Virus Antibody IgG CSF
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • Arbovirus
  • Flavivirus
  • WNV IgG, CSF