Epstein-Barr Virus Antibody to Early D Antigen (EA-D), IgG
0050225
Ordering Recommendation
May aid in the diagnosis of acute Epstein-Barr virus (EBV) infection and EBV reactivation in conjunction with other serologic studies. Molecular tests are preferred to detect EBV reactivation. Not a stand-alone test.
Mnemonic
EBV EAD
Methodology
Semi-Quantitative Chemiluminescent Immunoassay
Performed
Mon-Sun
Reported
1-2 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
 
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimen plainly as "acute" or "convalescent."  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma. Tissue or urine. Contaminated, grossly hemolyzed, or heat-inactivated specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Effective February 19, 2013

8.9 U/mL or less: Not Detected
9.0-10.9 U/mL: Indeterminate - Repeat testing in 10-14 days may be helpful.
11.0 U/mL or greater: Detected  
Interpretive Data
Interpretive information regarding serologic features of EBV-associated diseases is available at www.arupconsult.com/ebvdx .  
Note
EBV EA-D values obtained with different manufacturers' assay methods may not be used interchangeably.  The magnitude of the reported EBV EA-D level cannot be correlated to an endpoint titer.
CPT Code(s)
86663
Components
Component Test Code*Component Chart NameLOINC
0050225EBV Antibody to Early (D) Antigen IgG50969-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • EA-D IgG Ab
  • EAD Ab
  • EBNA Antibody
  • EBNA to EA-D
  • EBV Antibody to Early D Antigen
  • EBV Nuclear Antibody