Diphtheria Antibody, IgG
0050210
 
Ordering Recommendation
Mnemonic
DIP
Methodology
Quantitative Multiplex Bead Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. "Pre" and "post" vaccination specimens should be submitted together for testing. "Post" specimen should be drawn 30 days after immunization.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL) Mark specimens clearly as "Pre-Vaccine" or "Post-Vaccine". If shipped separately, "Post" specimen must be received within 60 days of "Pre" specimen.  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma or other body fluids.  
Remarks
 
Stability
After separation from the cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Antibody concentration of > 0.1 IU/mL is usually considered protective.
Interpretive Data
Responder status is determined according to the ratio of a one-month post-vaccination specimen to pre-vaccination concentration of diphtheria IgG antibody as follows:

1. If the post-vaccination concentration is less than 1.0 IU/mL, the patient is considered a nonresponder.
2. If the post-vaccination concentration is greater than or equal to 1.0 IU/mL, a patient with a ratio of less than 1.5 is a nonresponder, a ratio of 1.5 to less than 3.0, is a weak responder, and a ratio of 3.0 or greater, is a good responder.
3. If the pre-vaccination concentration is greater than 1.0 IU/mL, it may be difficult to assess the response based on a ratio alone. A post-vaccination concentration above 2.5 IU in this case is usually adequate.

See Compliance Statement B: www.aruplab.com/CS
Note
CPT Code(s)
86317
Components
Component Test Code*Component Chart Name
0050210Diphtheria Antibody, IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • Corynebacterium diphtheriae Antitoxin
  • Diphtheria Antitoxoid
  • Diptheria Vaccine Response