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IA-2 Antibody
0050202
Ordering Recommendation

•If pursuing antibody testing to determine autoimmune diabetes mellitus, perform at least 2 antibody tests. Other antibody tests include Glutamic Acid Decarboxylase Antibody (2001771), Insulin Antibody (0099228), Islet Cell Cytoplasmic Antibody, IgG (0050138), and Zinc Transporter 8 Antibody (2006196}.
•Most useful to establish autoimmumne etiology in previously diagnosed type 1 DM.
•Do not use to differentiate type 1 versus type 2 DM, for most cases.

Mnemonic
IA-2
Methodology
Quantitative Radioimmunoassay
Performed
Mon, Fri
Reported
2-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube or plain red.  
Specimen Preparation
Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma. Hemolyzed or lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 2 months  
Reference Interval
0.0-0.8 Kronus Units/mL
Interpretive Data
A value greater than 0.8 Kronus Units/mL is considered positive for IA-2 Antibodies.
Kronus Units are arbitrary. Kronus Units=U/mL


Note
CPT Code(s)
86341
Components
Component Test Code*Component Chart NameLOINC
0050202IA-2 Antibody31209-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-IA2 Antibodies
  • IA-2
  • ICA-512
  • Islet Antigen 2
  • Islet Cell Antibody
  • Islet Cell Antigen (ICA) 512
  • Tyrosine Phosphatase-Like Protein Antibodies
  • tyrosine phosphatase-related islet antigen 2