Cryoglobulin, Qualitative
0050185
Ordering Recommendation
 
Mnemonic
CRYGB
Methodology
Qualitative Cold Precipitation
Performed
Sun-Sat
Reported
3-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Fasting specimen required.  
Collect
Plain red tube.  
Specimen Preparation
1) Draw approximately 7 mL of blood into a pre-warmed (37°C) plain red tube. Alternatively: draw into a pre-warmed (37°C) syringe and immediately transfer blood to a pre-warmed (37°C) plain red tube. 2) Maintain collected blood at 37°C until clotting is complete. 3) Separate serum from cells within 1 hour of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) See Remarks.  
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated.  
Unacceptable Conditions
Plasma. Serum separator tubes (SST or clot-activating tubes). Grossly hemolyzed or lipemic specimens.  
Remarks
Proper collection and transport of specimen is critical to the outcome of the test. Submitting quantities less than 3 mL may affect the sensitivity of the test.  
Stability
After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable  
Reference Interval
Negative at 72 hours.  
Interpretive Data
 
Note
The specimen is examined daily for the presence or absence of cryoglobulins over a period of three days. Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular diseases, hepatitis C infection and infections such as infectious mononucleosis and cytomegalovirus disease. They may also be found in low levels in apparently healthy individuals.
CPT Code(s)
82595
Components
Component Test Code*Component Chart Name
0050185Cryoglobulin, Qualitative
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cryocrit
  • Cryoglobulins/cryoglobulins
  • Cryoprotein
  • Qualitative cryoglobulin