Cryoglobulin, Qualitative
Ordering Recommendation

Aids in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.

Qualitative Cold Precipitation
3-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Fasting specimen required. 
Plain red tube. 
Specimen Preparation
1) Draw approximately 7 mL of blood into a pre-warmed (37°C) plain red tube. Alternatively: draw into a pre-warmed (37°C) syringe and immediately transfer blood to a pre-warmed (37°C) plain red tube. 2) Maintain collected blood at 37°C until clotting is complete. 3) Separate serum from cells within 1 hour of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) See Remarks. 
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated. 
Unacceptable Conditions
Plasma. Serum separator tubes (SST or clot-activating tubes). Grossly hemolyzed or lipemic specimens. 
Proper collection and transport of specimen is critical to the outcome of the test. Submitting quantities less than 3 mL may affect the sensitivity of the test. 
After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable 
Reference Interval
Negative at 72 hours.
Interpretive Data

The specimen is examined daily for the presence or absence of cryoglobulins over a period of three days. Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular diseases, hepatitis C infection and infections such as infectious mononucleosis and cytomegalovirus disease. They may also be found in low levels in apparently healthy individuals.
Hotline History
Component Test Code*Component Chart NameLOINC
0050185Cryoglobulin, Qualitative5117-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Cryoglobulins/cryoglobulins
  • Cryoprotein
  • Qualitative cryoglobulin