C-Reactive Protein, High Sensitivity
Ordering Recommendation
Not recommended for general cardiovascular disease risk assessment in asymptomatic adults. May aid in CVD risk stratification in specific populations.
Quantitative Immunoturbidimetry
Within 24 hours  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Serum separator tube. Also acceptable: Plasma separator tube, pink (K2EDTA), or green (lithium heparin).  
Specimen Preparation
Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Hemolyzed specimens.  
After separation from cells: Ambient: 11 days; Refrigerated: 2 months; Frozen: 1 year  
Reference Interval
3.0 mg/L or less  
Interpretive Data
Patients with higher hs-CRP concentrations are more likely to develop stroke, myocardial infarction, and severe peripheral vascular disease.

CRP is a nonspecific marker of inflammation and a variety of conditions other than atherosclerosis may cause elevated concentrations. If the first result is greater than 3.0 mg/L, recommend repeating test at least 2 weeks later in a metabolically stable state, free of infection or acute illness. The lower of the two results should be used to determine the patient's risk.

Significantly decreased CRP values may result in specimens from patients treated with carboxypenicillins.
hs-​CRP results are used to assign risk as follows (Clin Chem 2009; 55:378-​84):  
Less than 1.0 mg/L
1.0-​3.0 mg/L
3.1-​9.9 mg/L
Greater than 9.9 mg/L
Low risk
Average risk
High risk
Very high risk
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0050182CRP, High Sensitivity30522-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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