Coccidioides Antibody, IgM by ELISA
0050178
Ordering Recommendation
Not recommended as a stand-alone test. For diagnosis of coccidioidomycosis (Valley fever), refer to Coccidioides Antibodies Panel, Serum by CF, ID, ELISA (0050588) which combines complement fixation, immunodiffusion, and enzyme-linked immunosorbent assays.
Mnemonic
COCCI M
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
- Patient Preparation
- Collect
- Serum Separator Tube (SST).
- Specimen Preparation
- Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.
- Storage/Transport Temperature
- Refrigerated.
- Unacceptable Conditions
- Contaminated, hemolyzed, or severely lipemic specimens.
- Remarks
- Mark specimens plainly as "acute" or "convalescent."
- Stability
- After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
| 0.9 IV or less | Negative - No significant level of Coccidioides IgM antibody detected. |
| 1.0-1.4 IV | Equivocal - Questionable presence of Coccidioides IgM antibody detected. Repeat testing in 10-14 days may be helpful. |
| 1.5 IV or greater | Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection. |
Interpretive Data
In most symptomatic patients, IgM antibody usually appears by the second week of infection and disappears by the fourth month. Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.
Note
Negative fungal serology does not rule out the possibility of current infection.
Hotline History
View Hotline History
CPT Code(s)
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050178 | Coccidioides Antibody, IgM by ELISA | 7827-9 |
Aliases
- Cocci IgM
- Coccidioides IgM antibody
- San Joaquin Fever antibodies
- Valley fever antibodies