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Coccidioides Antibody, IgM by ELISA
0050178
Ordering Recommendation

Not recommended as a stand-alone test. Refer to Coccidioides Antibodies Panel, Serum by CF, ID, ELISA (0050588), which combines complement fixation, immunodiffusion, and enzyme-linked immunosorbent assays.

Mnemonic
COCCI M
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon-Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube OR CSF. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum OR CSF to an ARUP Standard Transport Tube. (Min: 0.15 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as acute or convalescent. 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Contaminated, hemolyzed, or severely lipemic specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
0.9 IV or less: Negative - No significant level of Coccidioides IgM antibody detected.
1.0-1.4 IV: Equivocal - Questionable presence of Coccidioides IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater: Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.
Interpretive Data
In most symptomatic patients, IgM antibodies usually appear by the second week of infection and disappear by the fourth month. Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.

Note
Negative fungal serology does not rule out the possibility of current infection.
CPT Code(s)
86635
Components
Component Test Code*Component Chart NameLOINC
0050178Coccidioides Antibody, IgM by ELISA33510-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cocci IgM
  • Coccidioides IgM antibody
  • San Joaquin Fever antibodies
  • Valley fever antibodies