Beta-2 Transferrin
0050047
Ordering Recommendation
Aids in diagnosis of CSF leak.
Mnemonic
B2TRNSF
Methodology
Qualitative Immunofixation Electrophoresis
Performed
Sun-Sat
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
- Patient Preparation
- Collect
- Aural or nasal fluid in sterile container.
- Specimen Preparation
- Transport 2 mL aural or nasal fluid in a tube without preservative. (Min: 1 mL aural or nasal fluid)
- Storage/Transport Temperature
- Refrigerated.
- Unacceptable Conditions
- Remarks
- Stability
- Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 weeks
Reference Interval
None detected
Interpretive Data
Detection of a beta-2 transferrin band by IFE is diagnostic for the presence of cerebrospinal fluid (CSF). This test is useful in the differential diagnosis for CSF otorrhea or CSF rhinorrhea. Beta-2 transferrin is not detected by this methodology in normal serum, tears, saliva, sputum, nasal, or aural fluid.
The performance characteristics of this test were determined by ARUP Laboratories, Inc.
The performance characteristics of this test were determined by ARUP Laboratories, Inc.
Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Note
The beta-2 transferrin protein assay by IFE methodology is not a reliable method for detecting human perilymph due to the low sensitivity of the assay.
Hotline History
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CPT Code(s)
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050047 | Beta-2 Transferrin | 13876-8 |
Aliases
- Cerebrospinal Fluid Leakage
- Transferrin, Spinal Fluid
- B2 Transferrin
- CSF Leakage Detection
- CSF Specific Transferrin
- CSF-Specific Transferrin
- Desialated Transferrin
- Tau CSF Protein
- Transferrin B2