Estrogen/Progesterone Receptor with Interpretation by Immunohistochemistry
Ordering Recommendation

Aid in the prediction of response to antiestrogen agents for patients with ductal carcinoma in situ (DCIS) and invasive cancers.

Within 4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Immunohistochemistry Stain Form Recommended  (ARUP form #32978)Immunohistochemistry Stain Form Recommended (ARUP form #32978)
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Tumor tissue. 
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue no later than 1 hour after removal from patient. Fixative duration: 6-72 hours. If sending precut slides, do not oven bake. Transport tissue block or 5 unstained (3-5 micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800)522-2787.(Min: 4 slides).If sending precut slides, do not oven bake. 
Storage/Transport Temperature
Room temperature or refrigerated. Ship in cooled container during summer months. 
Unacceptable Conditions
Paraffin block with no tumor tissue remaining. Specimens with fixation delayed for more than one hour. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Biopsies fixed for less than 6 hours and greater than 72 hours. Cytology specimens fixed in alcohol. 
Document time from tissue acquisition to fixation and fixation duration on submitting requisition or enter at time of order. Include surgical pathology report. 
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable 
Reference Interval
Interpretive Data
Refer to report.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
Component Test Code*Component Chart NameLOINC
0049200Estrogen Receptor IP40556-3
0049201% of Nuclei Staining (ER)14228-1
0049205Progesterone Receptor IP10480-2
0049206% of Nuclei Staining (PR)14230-7
0049217Estrog/Progest Receptor Interpretation19146-0
2003377Estrogen Receptor Intensity
2003378Progesterone Receptor Intensity
2011429EstrogRecp IHC Internal Control Staining
2011430ProgstRecp IHC Internal Control Staining
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • ER and PR IHC
  • ER, PGR staining
  • ER/PgR
  • ERA & PRA
  • ERPR
  • Steroid Receptor Assay