Aneuploidy Panel by FISH
Ordering Recommendation

Panel is ONLY utilized for newborns with suspected aneuploidy. Included are probes for trisomy 13, trisomy 18, trisomy 21, and the X and Y sex chromosomes. Note that if chromosome analysis is also ordered, a preliminary chromosome report will be issued based on 10 cells from a 48-hour culture.

Fluorescence in situ Hybridization
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Cytogenetic Test Request Form Recommended (ARUP form #43097)Cytogenetic Test Request Form Recommended (ARUP form #43097)
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Green (sodium heparin).  
Specimen Preparation
Do not freeze or expose to extreme temperatures.  Transport 5 mL whole blood. (Min: 1 mL)  
Storage/Transport Temperature
Room temperature.  
Unacceptable Conditions
Frozen specimens. Clotted specimens.  
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
By report
Interpretive Data

Compliance Statement C: For human genetic inheritable conditions and mutations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
This panel is ONLY utilized for newborns with suspected aneuploidy. This panel includes probes for trisomy 13, trisomy 18, trisomy 21 and X and Y. For other applications, please contact ARUP's genetic counselor at (800) 242-2787 extension 3922 for additional information.
These studies involve culturing of living cells; therefore, turnaround times given represent average times which are subject to multiple variables. After specimen receipt, results are generally available in an average of 4 days.
A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth

This test must be ordered using Cytogenetic test request form #43097 or through your ARUP interface. Submit the Patient History for Cytogenetic (Chromosome) Studies with the electronic packing list (available at

Specimen and completed test request form, including clinical indication, must be received within 48 hours of collection.
CPT Code(s)
88271 x5; 88275 x5; 88291
Component Test Code*Component Chart NameLOINC
0040209Aneuploidy Panel by FISH50684-0
2002194EER Aneuploidy Panel by FISH11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Common Trisomy FISH panel
  • Newborn FISH panel