Additional Technical Information
- Patient Preparation
- Plasma separator tube or serum separator tube. Also acceptable: Green (sodium or lithium heparin), or pink (K2EDTA).
- Specimen Preparation
- Transport 3 mL whole blood. (Min: 1 mL)
- Storage/Transport Temperature
- Unacceptable Conditions
- Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
Background Information for Haptoglobin (HP) Genotyping:
Characteristics: Hp genotype is a predictor of cardiovascular disease in diabetic patients. There is no known correlation between the Hp genotype and cardiovascular risk in nondiabetics. Diabetics with the Hp 2-2 genotype are five times more likely to have cardiovascular disease than those with the Hp 1-1 genotype and may benefit from vitamin E treatment. Diabetics who have the Hp 1-1 genotype are at decreased risk for developing microvascular complications such as nephropathy, retinopathy or for restenosis following percutaneous coronary angioplasty.
Incidence: The Hp 1 and Hp 2 allele frequencies vary across populations. Asians have the highest frequency of Hp 2. The Hp 2-2 genotype is 36 percent in Northwestern Europeans.
Inheritance: Autosomal recessive.
Alleles Tested: Hp 1 and Hp 2.
Clinical Sensitivity: Unknown.
Methodology: Polymerase chain reaction and fluorescence monitoring.
Analytical Sensitivity and Specificity: 98 percent.
Limitations: Diagnostic errors can occur due to rare sequence variations. Anhaptoglobinemia (Hp0-0) or hypohaptoglobinemia (Hp 1-0 or Hp 2-0) may be misclassified depending on the cause of lack of gene expression.
This test is performed pursuant to an agreement with Roche Molecular Systems, Inc.
This test is performed pursuant to an agreement with Synvista, Inc.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.
See Compliance Statement C: www.aruplab.com/CS
|Component Test Code*||Component Chart Name|
|0040127||Haptoglobin (HP) Genotyping|
|2001313||HAPTO PCR Specimen|