SYT-SSX t(X;18) Translocations by RT-PCR
Ordering Recommendation
Molecular diagnosis of synovial sarcoma.
Reverse Transcription Polymerase Chain Reaction/Fluorescence Monitoring
RNA Isolation: Sun-Sat; Assay: Varies
4-7 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Tumor tissue.  
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport four 10-micron shavings. Also acceptable: Tissue block; will be returned after testing. Transport block(s) and/or shavings in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.  
Storage/Transport Temperature
Room temperature or refrigerated. Ship in cooled container during summer months.  
Unacceptable Conditions
No tumor in tissue. Specimens fixed/processed in alternative fixatives (alcohol, Prefer®) or heavy metal fixatives. Decalcified specimens. Tissue on slides.  
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
By report
Interpretive Data
Refer to report.

This test is performed pursuant to an agreement with Roche Molecular Systems, Inc.

See Compliance Statement B:
A positive result indicates the presence of a t(X;18) chromosomal translocation. A negative result does not entirely exclude the presence of a t(X;18) chromosomal translocation.
CPT Code(s)
81401 x2
Component Test Code*Component Chart Name
0040119SYT-SSX t(X;18) Translocation
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at
Cross References
  • SSX
  • SYT
  • SYT-SSX fusion
  • t(X;18)
  • X;18