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Protein C and S Panel, Functional
0030182
Ordering Recommendation

Acceptable panel to detect protein C and S deficiencies.  Preferred test for detecting protein S deficiency is Protein S Free, Antigen (0098894). Do not order if the individual has been on warfarin therapy in the previous 2-4 weeks.

Mnemonic
C/S PANEL
Methodology
Electromagnetic Mechanical Clot Detection
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
CRITICAL FROZEN.  Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. EDTA plasma, clotted or hemolyzed specimens.  
Remarks
Include list of medications.  
Stability
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months  
Reference Interval
Test Number
Components
Reference Interval
0030113Protein C, FunctionalEffective November 17, 2014
AgeReference Interval
1-4 days17-53%
5-29 days20-64%
30-89 days21-65%
90-179 days28-80%
180-364 days37-81%
1-6 years40-92%
7-9 years70-142%
10-11 years68-143%
12-13 years66-162%
14-15 years69-170%
16-17 years70-171%
18 years and older83-168%

0030114Protein S, FunctionalMale
1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-5 years: 62-120%
6 years:  62-130%
7-9 years: 66-140%
10-11 years: 65-139%
12-13 years: 72-139%
14-15 years: 68-145%
16-17 years: 77-167%
18 years and older: 66-143%

Female

1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-5 years: 62-120%
6 years:  62-130%
7-9 years: 62-151%
10-11 years: 65-142%
12-13 years: 70-140%
14-15 years: 55-145%
16-17 years: 51-147%
18 years and older: 57-131%


Interpretive Data
Refer to report.


Note
CPT Code(s)
85303; 85306
Components
Component Test Code*Component Chart NameLOINC
0030113Protein C Functional27819-2
0030114Protein S Functional27822-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Protein C & S
  • Protein C and S Activity