Lupus Anticoagulant Reflexive Panel
Ordering Recommendation

Use for unexplained prolonged PTT or for patients with a significant probability of having antiphospholipid syndrome (APS).  For APS, order with Cardiolipin Antibodies, IgG and IgM (0099344) and Beta-2 Glycoprotein 1 Antibodies, IgG and IgM (anti-beta[2]GP1) (0050321).

Electromagnetic Mechanical Clot Detection
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Light blue (sodium citrate). Refer to Specimen Handling at for hemostasis/thrombosis specimen handling guidelines. 
Specimen Preparation
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 2 mL) 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Serum. EDTA plasma, clotted or hemolyzed specimens. 
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C or below: 3 months; Frozen at -70°C or below: 18 months 
Reference Interval
Effective August 21, 2017
Test Number
Reference Interval
Dilute Russell Viper Venom Time (dRVVT)33-44 seconds
Dilute Russell Viper Venom (dRVVT) 1:1 Mix (performed if dRVVT > 44 seconds)33-44 seconds
Dilute Russell Viper Venom Time (dRVVT) Confirmation Test (performed if dRVVT 1:1 Mix > 44 seconds)Negative
Prothrombin Time12.0-15.5 seconds
Partial Thromboplastin Time32-48 seconds
Thrombin Time14.7-19.5 seconds
Reptilase TimeLess than 22.0 seconds
PTT Heparin Neutralized32-48 seconds
Partial Thromboplastin Time 1:1 Mix (performed if PTT > 48 seconds)32-48 seconds
Platelet Neutralization Procedure (performed if PTT 1:1 Mix > 48 seconds)Negative
Hexagonal Phospholipid NeutralizationNegative

Interpretive Data

If PTT and dRVVT are normal, then no further testing is performed. If PTT is abnormal, Thrombin Time is added. If Thrombin Time is normal, PTT 1:1 mix is added.  If Thrombin time is abnormal, Reptilase Time and PTT Heparin Neutralization is added. If PTT Heparin Neutralization is abnormal, PTT 1:1 mix is added.  If PTT 1:1 mix is abnormal, Platelet Neutralization procedure is added. If dRVVT is abnormal, dRVVT 1:1 mix is added. If dRVVT 1:1 mix is abnormal, dRVVT confirmation is added. If Platelet Neutralization procedure and dRVVT confirmation are normal or if one is normal and the other not done, Hexagonal Phospholipid Neutralization is added. Additional charges apply.
Hotline History
CPT Code(s)
85610; 85730; 85613; if reflexed, additional CPT codes may apply: 85670; 85635; 85730; 85525; 85732; 85597; 85613; 85598.
Component Test Code*Component Chart NameLOINC
0030079Lupus Anticoagulant Interpretation75882-1
0030082Hexagonal Phospholipid Neutral Reflex33930-9
0030084PTT-D Heparin Neutralized52123-7
0030184Platelet Neutralization (PTT-D, Confirm)15191-0
0030189dRVVT Confirmation50410-0
0030232PTT-LA Screen (PTT-D)34571-0
0030246Prothrombin Time5902-2
0030270Thrombin Time3243-3
0030296Reptilase Time6683-7
0030323PTT-D 1:1 Mix5946-9
0030352dRVVT Screen6303-2
0030353dRVVT 1:1 Mix75513-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • dRVVT 1:1 Mix
  • dRVVT Confirmation
  • dRVVT Screen
  • Hexagonal Phospholipid Neutral Reflex
  • Lupus 1
  • Lupus Anticoagulant
  • Lupus Anticoagulant Comprehensive
  • Lupus Anticoagulant with Reflex to Phospholipid Neutralization
  • Lupus Inhibitor
  • Platelet Neutralization
  • Prothrombin Time
  • PTT-D Heparin Neutralized
  • PTT-LA Screen
  • Reptilase Time
  • Thrombin Time