Lupus Anticoagulant Reflexive Panel
Ordering Recommendation
Use for unexplained prolonged PTT or for patients with a significant probability of having antiphospholipid syndrome (APS).  For APS, order with anticardiolipin (aCL) (0099344) and anti-beta-2-glycoprotein 1 (anti-β2GP1) (0050321) antibody IgG and IgM assays.
1-2 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Light blue (sodium citrate). Refer to Specimen Handling at for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. Anticoagulants other than indicated. Clotted, hemolyzed, or non-frozen specimens.  
Ambient: 4 hours; Refrigerated: 4 hours; Frozen at -20°C or below: 3 months; Frozen at -70°C or below: 18 months  
Reference Interval
Test Number Components Reference Interval
 Prothrombin Time 12.0-​15.5 seconds
 Partial Thromboplastin Time 32-​48 seconds
 Dilute Russell Viper Venom Time (dRVVT) 33-​44 seconds
 Thrombin Time 14.7-​19.5 seconds
 Reptilase Time Less than 22.0 seconds
 PTT Heparin Neutralized 32-​48 seconds
 Partial Thromboplastin Time 1:1 Mix (performed if PTT > 48 seconds) 32-​48 seconds
 Platelet Neutralization Procedure (performed if PTT 1:1 Mix > 48 seconds) Negative
 Dilute Russell Viper Venom (dRVVT) 1:1 Mix (performed if dRVVT > 44 seconds) 33-​44 seconds
 Dilute Russell Viper Venom Time (dRVVT) Confirmation Test (performed if dRVVT 1:1 Mix > 44 seconds) Negative
 Hexagonal Phospholipid Neutralization Negative
Interpretive Data
If PTT and dRVVT are normal, then no further testing is performed. If PTT is abnormal, Thrombin Time is added. If Thrombin Time is normal, PTT 1:1 mix is added.  If Thrombin time is abnormal, Reptilase Time and PTT Heparin Neutralization is added. If PTT Heparin Neutralization is abnormal, PTT 1:1 mix is added.  If PTT 1:1 mix is abnormal, Platelet Neutralization procedure is added. If dRVVT is abnormal, dRVVT 1:1 mix is added. If dRVVT 1:1 mix is abnormal, dRVVT confirmation is added. If Platelet Neutralization procedure and dRVVT confirmation are normal or if one is normal and the other not done, Hexagonal Phospholipid Neutralization is added. Additional charges apply.
CPT Code(s)
85610; 85730; 85613; if reflexed, additional CPT codes may apply: 85670; 85635; 85730; 85525; 85732; 85597; 85613; 85598.
Component Test Code*Component Chart Name
0030079Lupus Anticoagulant Interpretation
0030082Hexagonal Phospholipid Neutral Reflex
0030084PTT-D Heparin Neutralized
0030184Platelet Neutralization (PTT-D, Confirm)
0030189dRVVT Confirmation
0030232PTT-LA Screen (PTT-D)
0030246Prothrombin Time
0030270Thrombin Time
0030296Reptilase Time
0030323PTT-D 1:1 Mix
0030352dRVVT Screen
0030353dRVVT 1:1 Mix
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • dRVVT 1:1 Mix
  • dRVVT Confirmation
  • dRVVT Screen
  • Hexagonal Phospholipid Neutral Reflex
  • Lupus 1
  • Lupus Anticoagulant
  • Lupus Anticoagulant Comprehensive
  • Lupus Anticoagulant with Reflex to Phospholipid Neutralization
  • Lupus Inhibitor
  • Platelet Neutralization
  • Prothrombin Time
  • PTT-D Heparin Neutralized
  • PTT-LA Screen
  • Reptilase Time
  • Thrombin Time