Protein C and S Panel, Total, Antigen
Ordering Recommendation
Not recommended. Preferred tests for detection of protein C and S deficiencies are Protein C Functional (0030113) and Protein S Free Antigen (0098894). Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.
Submit With Order
Microlatex Particle-Mediated Immunoassay
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Lt. blue (sodium citrate). Refer to Specimen Handling at for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. Non-frozen or hemolyzed specimens.  
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months  
Reference Interval
Test Number Components Reference Interval
0030111Protein C, Total Antigen 1-​4 days: 17-​53%
5-​29 days: 20-​64%
30-​89 days: 21-​65%
90-​179 days: 28-​80%
180-​364 days: 37-​81%
1-​5 years: 40-​92%
6-​10 years: 45-​93%
11 years and older: 63-​153%
0030112Protein S, Total Antigen 1-​4 days: 12-​60%
5-​29 days: 22-​78%
30-​89 days: 33-​93%
90-​179 days: 54-​118%
180-​364 days: 55-​119%
1-​5 years: 54-​118%
6-​10 years: 41-​114%
11 years and older: Females: 63-​126%; Males: 84-​134%
Interpretive Data
Refer to report.
CPT Code(s)
85302; 85305
Component Test Code*Component Chart Name
0030111Protein C, Total Antigen
0030112Protein S, Total Antigen
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • Protein C & S, Antigen