Protein C and S Panel, Total, Antigen
Ordering Recommendation
Not recommended. Preferred tests for detection of protein C and S deficiencies are Protein C Functional (0030113) and Protein S Free Antigen (0098894). Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.
Microlatex Particle-Mediated Immunoassay
1-2 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Lt. blue (sodium citrate). Refer to Specimen Handling at for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. EDTA plasma or hemolyzed specimens.  
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months  
Reference Interval
Test Number Components Reference Interval
0030111Protein C, Total Antigen 1-​4 days: 17-​53%
5-​29 days: 20-​64%
30-​89 days: 21-​65%
90-​179 days: 28-​80%
180-​364 days: 37-​81%
1-​5 years: 40-​92%
6-​10 years: 45-​93%
11 years and older: 63-​153%
0030112Protein S, Total Antigen  
Age Male Female
1-​4 days 12-​60% 12-​60%
5-​29 days 22-​78% 22-​78%
30-​89 days 33-​93% 33-​93%
90-​179 days 54-​118% 54-​118%
180-​364 days 55-​119% 55-​119%
1-​5 years 54-​118% 54-​118%
6-​10 years 41-​114% 41-​114%
11 years and older 84-​134% 63-​126%
Interpretive Data
Refer to report.  
CPT Code(s)
85302; 85305
Component Test Code*Component Chart NameLOINC
0030111Protein C, Total Antigen27820-0
0030112Protein S, Total Antigen27823-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Protein C & S, Antigen