Protein S, Functional
0030114
 
Ordering Recommendation
Acceptable test for detecting protein S deficiency. Preferred test is Protein S Free, Antigen (0098894). Do not order if the individual has been on warfarin therapy in the previous 2-4 weeks.
Mnemonic
PROT S F
Methodology
Clotting
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 1.5 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. Non-frozen or hemolyzed specimens.  
Remarks
 
Stability
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months  
Reference Interval
Male
1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-5 years: 62-120%
6 years: 62-130%
7-9 years: 66-140%
10-11 years: 65-139%
12-13 years: 72-139%
14-15 years: 68-145%
16-17 years: 77-167%
18 years and older: 66-143%

Female

1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-5 years: 62-120%
6 years: 62-130%
7-9 years: 62-151%
10-11 years: 65-142%
12-13 years: 70-140%
14-15 years: 55-145%
16-17 years: 51-147%
18 years and older: 57-131%
Interpretive Data
Patients on warfarin may have decreased functional protein S values. Patients should be off warfarin therapy for two weeks for accurate measurement of functional protein S. Artificially increased functional protein S values may be due to heparin therapy or the presence of direct thrombin inhibitors or factor Xa inhibitors.
Note
CPT Code(s)
85306
Components
Component Test Code*Component Chart Name
0030114Protein S Functional
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • Functional Protein S
  • Protein S Activity, Plasma