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Protein S, Total Antigen
0030112
Ordering Recommendation
Not recommended for detecting protein S deficiency; preferred test is Protein S Free, Antigen (0098894). Use to subtype deficiency in known protein S-deficient individuals in combination with Protein S Free, Antigen (0098894), or Protein S, Functional (0030114). Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.
Mnemonic
PROT S
Methodology
Microlatex Particle-Mediated Immunoassay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 1.5 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. EDTA plasma, clotted or hemolyzed specimens.  
Remarks
 
Stability
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months  
Reference Interval
AgeMaleFemale
1-4 days12-60%12-60%
5-29 days22-78%22-78%
30-89 days33-93%33-93%
90-179 days54-118%54-118%
180-364 days55-119%55-119%
1-5 years54-118%54-118%
6-10 years41-114%41-114%
11 years and older84-134%63-126%

Interpretive Data
Patients on warfarin may have decreased protein S values. Patients should be off warfarin therapy for two weeks for accurate measurement of protein S.


Note
CPT Code(s)
85305
Components
Component Test Code*Component Chart NameLOINC
0030112Protein S, Total Antigen27823-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Free Protein S Antigen
  • Protein S Antigen, S Protein Antigen
  • Total Protein S Antigen