Protein C, Functional with Reflex to Protein C, Total Antigen
0030041
Ordering Recommendation
Acceptable test to detect and subtype protein C deficiency. Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.
Mnemonic
PROT CF R
Methodology
Electromagnetic Mechanical Clot Detection/Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. EDTA plasma or hemolyzed specimens.  
Remarks
 
Stability
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months  
Reference Interval
By report  
Interpretive Data
Patients on warfarin may have decreased protein C values. Patients should be off warfarin therapy for two weeks for accurate measurement of protein C levels. Artificially increased functional protein C values may be due to heparin therapy or the presence of direct thrombin inhibitors or factor Xa inhibitors.  
Note
If Protein C functional is decreased, then Protein C, Total Antigen, will be added. Additional charges apply.
CPT Code(s)
85303; if reflexed, add 85302
Components
Component Test Code*Component Chart NameLOINC
0030113Protein C Functional27819-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Protein C Profile
  • Protein C, functional and total