Protein C, Functional with Reflex to Protein C, Total Antigen
0030041
 
Ordering Recommendation
Acceptable test to detect and subtype protein C deficiency. Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.
Mnemonic
PROT CF R
Methodology
Clotting/Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. Non-frozen or hemolyzed specimens. Anticoagulants other than citrate.  
Remarks
 
Stability
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months  
Reference Interval
By report
Interpretive Data
Patients on warfarin may have decreased protein C values. Patients should be off warfarin therapy for two weeks for accurate measurement of protein C levels. Artificially increased functional protein C values may be due to heparin therapy or the presence of direct thrombin inhibitors or factor Xa inhibitors.
Note
If Protein C functional is decreased, then Protein C, Total Antigen, will be added. Additional charges apply.
CPT Code(s)
85303; if reflexed, add 85302
Components
Component Test Code*Component Chart Name
0030113Protein C Functional
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • Protein C Profile
  • Protein C, functional and total