Heavy Metals Panel 6, Urine with Reflex to Arsenic Fractionated
Ordering Recommendation
Quantitative Inductively Coupled Plasma-Mass Spectrometry
1-4 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Diet, medication, and nutritional supplements may introduce interfering substances.  Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, non-essential over-the-counter medications (upon the advice of their physician), and avoid shellfish and seafood for 48 to 72 hours. High concentrations of iodine may interfere with elemental testing.  Abstinence from iodine-containing medications or contrast agents for at least 1 month prior to collecting specimens for elemental testing is recommended.  
24-hour or random urine collection. Specimen must be collected in a plastic container and should be refrigerated during collection. ARUP studies indicate that refrigeration of urine alone, during and after collection, preserves specimens adequately if tested within 14 days of collection.  
Specimen Preparation
Transfer 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 2 mL) Record total volume and collection time interval on transport tube and on test request form.  
Storage/Transport Temperature
Refrigerated. Also acceptable: Room temperature or frozen.  
Unacceptable Conditions
Urine collected within 48 hours after administration of a gadolinium (Gd) containing contrast media (may occur with MRI studies). Acid preserved urine.  
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
Test Number Components Reference Interval
 Arsenic, Urine0-​35.0 µg/L (based on Biological Exposure Index)
 Arsenic, Urine (24-​hour)0-​50.0 µg/d
 Arsenic per gram of creatinineNo reference interval (µg/g CRT)
0020734Arsenic, Fractionated, Urine  
Test Number Components Reference Interval
 As Organic Refer to report
 Arsenic Total Inorganic Refer to report
 Arsenic, Methylated Refer to report
 Cadmium, Urine -​ per volume 0.0-​2.6 µg/L
 Cadmium, Urine -​ per 24h 0.0-​3.3 µg/d
 Cadmium, Urine -​ ratio to CRT 0.0-​3.0 µg/g crt
 Copper, Urine0.2-​8.0 µg/dL
 Copper, Urine (24-​hour)3-​50 µg/d
 Copper per gram of creatinineNo reference interval (µg/g crt)
 Lead, Urine0-​23 µg/L
 Lead, Urine (24-​hour)0-​31 µg/d
 Lead per gram of creatinineNo reference interval (µg/g crt)
 Mercury, Urine -​ per 24h 0-​15 µg/d
 Mercury, Urine -​ per volume 0-​10 µg/L
 Mercury, Urine -​ ratio to CRT Less than or equal to 35 µg/gCRT
 Zinc, Urine15-​120 µg/dL
 Zinc, Urine (24-​hour)150-​1200 µg/d
 Zinc per gram of creatinineNo reference interval (µg/g crt)
 Creatinine, Urine -​ per volume No reference interval
0020473Creatinine, 24-​Hour Urine  
Age Male Female
3-​8 years 140-​700 mg/d 140-​700 mg/d
9-​12 years 300-​1300 mg/d 300-​1300 mg/d
13-​17 years 500-​2300 mg/d 400-​1600 mg/d
18-​50 years 1000-​2500 mg/d 700-​1600 mg/d
51-​80 years 800-​2100 mg/d 500-​1400 mg/d
81 years and older 600-​2000 mg/d 400-​1300 mg/d
Interpretive Data
The ACGIH Biological Exposure Index (BEI) for arsenic in urine is 35 µg/L. The ACGIH BEI is based on the sum of inorganic and methylated species. For specimens with a total arsenic concentration between 35-2000 µg/L, fractionation is automatically performed to determine the proportions of inorganic, methylated and organic species. It may be appropriate to request fractionation for specimens with a total arsenic greater than 30 µg/gCRT despite a total arsenic concentration less than 35 µg/L. If low-level chronic poisoning is suspected, the µg/gCRT ratio may be a more sensitive indicator of arsenic exposure than the total arsenic concentration.  
If total arsenic concentration is between 35-2000 ug/L, then Arsenic, Fractionated, will be added to determine the proportion of organic, inorganic, and methylated forms. Additional charges apply.
CPT Code(s)
82175; 82300; 82525; 83655; 83825; 84630; if reflexed, add 82175
Component Test Code*Component Chart Name
0020100Copper, Urine - per volume
0020101Copper, Urine - per 24h
0020102Zinc, Urine - per volume
0020103Zinc, Urine - per 24h
0020207Creatinine, Urine - per volume
0020208Creatinine, Urine - per 24h
0025001Arsenic Urine - per volume
0025002Arsenic Urine - per 24h
0025038Cadmium, Urine - ratio to CRT
0025041Cadmium, Urine - per 24h
0025042Cadmium, Urine - per volume
0025051Mercury, Urine - per 24h
0025052Mercury, Urine - per volume
0025054Mercury, Urine - ratio to CRT
0025058Arsenic, Urine - ratio to CRT
0025061Lead, Urine - per 24h
0025062Lead, Urine - per volume
0025063Zinc, Urine - ratio to CRT
0025064Copper, Urine - ratio to CRT
0025065Lead, Urine - ratio to CRT
0097110Total Volume
0097111Hours Collected
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Arsenic
  • As fractionation
  • Cadmium
  • Cd
  • Copper
  • Cu
  • heavy metals urine screen
  • Hg
  • Inorganic As
  • Lead
  • Mercury
  • methylated As
  • Organic As
  • Pb
  • Zinc
  • Zn