Cobalt, Serum or Plasma
0025037
Ordering Recommendation
Submit With Order
Mnemonic
COBALT S
Methodology
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Performed
Tue, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).  
Collect
Royal blue (no additive) or Royal blue (EDTA)  
Specimen Preparation
Centrifuge; Do not allow serum to remain on cells. Transfer 2 mL serum or plasma to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)  
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated or frozen.  
Unacceptable Conditions
Separator tubes. Specimens that are not separated from the red cells, or clot, within 6 hours.  
Remarks
 
Stability
If the specimen is drawn and stored in the appropriate container, the trace element values do not change with time.  
Reference Interval
Less than or equal to 1.0 µg/L
Interpretive Data
Serum cobalt levels can be used in the assessment of occupational exposure or toxic ingestion and is the preferred specimen type for evaluating metal ion release from metal-on-metal joint arthroplasty. Serum cobalt levels may be increased in asymptomatic patients with metal-on-metal prosthetics and should be considered in the context of the overall clinical scenario. Symptoms associated with cobalt toxicity vary based on route of exposure, and may include cardiomyopathy, allergic dermatitis, pulmonary fibrosis, cough and dyspnea.
Note
Elevated results from noncertified trace element-free tubes may be due to contamination. Elevated concentrations of trace elements in serum should be confirmed with a second specimen collected in a trace element-free tube, such as royal blue sterile tube (no additive).
CPT Code(s)
83018
Components
Component Test Code*Component Chart Name
0025037Cobalt, Serum or Plasma
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • Co
  • COS
  • Plasma cobalt level