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Procalcitonin
0020763
Ordering Recommendation

Assess risk of progression to severe sepsis and septic shock in critically ill patients upon admission to ICU. Use in conjunction with other laboratory findings.

Mnemonic
PCT
Methodology
Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
The same specimen type (serum, plasma) should be used throughout the patient's clinical course. 
Collect
Plasma Separator Tube (PST) or Serum Separator Tube (SST). 
Specimen Preparation
Allow serum to sit for 15-20 minutes for proper clot formation and to ensure the absence of fibrin in the serum which can interfere with this assay. Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Specimens collected in citrate anticoagulant. 
Remarks
 
Stability
After separation from cells: Ambient: 24 hours; Refrigerated: 5 days; Frozen: 15 days 
Reference Interval
Less than 0.07 ng/mL
Interpretive Data
A correction has been applied to optimize cutoffs established for the BRAHMS PCT sensitive KRYPTOR assay.

Procalcitonin > 2.00 ng/mL:
Procalcitonin levels above 2.00 ng/mL on the first day of ICU admission represent a high risk for progression to severe sepsis and/or septic shock.

Procalcitonin < 0.50 ng/mL:
Procalcitonin levels below 0.50 ng/mL on the first day of ICU admission represent a low risk for progression to severe sepsis and/or septic shock.

If the procalcitonin measurement is performed shortly after the systemic infection process has started (usually less than 6 hours), these values may still be low. As various non-infectious conditions are known to induce procalcitonin as well, procalcitonin levels between 0.50 ng/mL and 2.00 ng/mL should be reviewed carefully to take into account the specific clinical background and condition(s) of the individual patient.

Note
Procalcitonin levels below 0.50 ng/mL do not exclude an infection, because localized infections (without systemic signs) may also be associated with such low levels.
Hotline History
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Components
Component Test Code*Component Chart NameLOINC
0020764Procalcitonin33959-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • antibiotic adequacy
  • PCT
  • Procalcitonin Sepsis Biomarker
  • ProCT