Copper, Liver
0020694
Ordering Recommendation
 
Mnemonic
CU-LIVER
Methodology
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Performed
Mon, Wed, Fri
Reported
2-6 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Liver tissue obtained with an 18 gauge needle.  
Specimen Preparation
Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container such as a royal blue (no additive).  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Specimens less than 0.25 mg (dry weight). Paraffin blocks that have been processed with Hollandes or other copper-containing stain.  
Remarks
  
Stability
Paraffin block, preserved (formalin), or dried: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely
Fresh tissue:
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Indefinitely  
Reference Interval
15-55 µg/g of tissue.  
Interpretive Data
Hepatic copper concentrations approach or exceed 250 µg/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions. Results inconsistent with other findings may reflect heterogeneity in hepatic copper distribution.

See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
 
CPT Code(s)
82525
Components
Component Test Code*Component Chart NameLOINC
0020695Tissue Weight29638-4
0020697Hepatic Copper Concentration by Weight56126-6
2004962EER Copper, Liver11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Copper Tissue
  • Cu
  • Hepatic Copper Concentration
  • Metals, Tissue
  • Quantitative Copper, Tissue