Helicobacter pylori Breath Test, Adult (INACTIVE as of 08/18/14: Refer to 2010476)
Ordering Recommendation
Qualitative Spectrophotometry
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
This test requires the patient to drink a solution (Pranactin-Citric) containing aspartame, citric acid, and mannitol. Caution should be taken when administering this test to phenylketonurics and patients with hypersensitivities to these ingredients. The patient should fast and abstain from smoking for 1 hour prior to test administration. The patient should not have taken antibiotics, bismuth preparations, or proton pump inhibitors for at least 14 days. Allow 4 weeks after cessation of definitive therapy before performing this test. Additional warnings and precautions are included with the BreathTek UBT kit. Please review these carefully. 
BreathTek UBT Kit. (ARUP Supply #33396) Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. Kits are provided at a cost of $50 each. 
Specimen Preparation
1) Label breath collection bags with patient name, MRN, date and time of collection, and indicate Pre (blue) or Post (pink).
2) Collect the baseline (Pre) breath specimen according to the instructions in the BreathTek UBT kit.
3) After the allotted time, collect the Post breath specimen according to the instructions in the kit. 
Storage/Transport Temperature
Unacceptable Conditions
Bags not fully inflated or only one of the two bags submitted. Breath collected in tubes. Post breath specimens collected earlier than 13 minutes or later than 18 minutes after patient drinks the testing solution. Pediatric specimens from persons 17 years or younger. 
For a valid result, the post breath specimen must be collected 13 to 18 minutes after the patient drinks the Pranactin-Citric solution. 
Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable 
Reference Interval
Reference intervals for pediatric patients have not been established.
Interpretive Data
A negative result does not rule out the possibility of H. pylori infection. If clinical signs are suggestive of H. pylori infection, retest with a new specimen or an alternate method. Known causes of false-negative results include:
1. Use of antimicrobials, proton pump inhibitors, and bismuth preparations during the preceding 2 weeks.
2. Administration of the breath test less than 4 weeks after completion of definitive therapy to eradicate H. pylori.
3. Premature or late collection of the post-dose specimen.

Known causes of false-positive results include:
1. Patients with achlorhydria.
2. Rinsing the testing solution in the mouth, which can allow contact with urease-positive bacteria.
3. The presence of other gastric spiral organisms such as Helicobacter heilmanii.

The post-dose sample must be collected within 13 to 18 minutes post dose to prevent false negatives.
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0020646H. pylori Breath Test29891-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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