Zinc Protoporphyrin (ZPP), Whole Blood
0020605
 
Ordering Recommendation
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Mnemonic
ZPP
Methodology
Quantitative Hematofluorometry
Performed
Mon-Fri
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA); Royal blue, (EDTA), tan (EDTA), or pink (K2 EDTA). Use royal blue (EDTA) tube when also testing for lead.  
Specimen Preparation
Transport 1 mL whole blood. (Min: 0.2 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Specimens not collected in EDTA. Clotted, frozen, or hemolyzed specimens.  
Remarks
 
Stability
Ambient: 30 hours; Refrigerated: 5 weeks; Frozen: Unacceptable  
Reference Interval
0-69 µmol ZPP/ mol Hem
Interpretive Data
Note
Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria. Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.


A more specific test for free protoporphyrin is Porphyrins, Serum Total (0080429). Erythrocyte Porphyrin (EP), Whole Blood (0020610), measures free protoporphyrin and zinc protoporphyrin.
CPT Code(s)
84202
Components
Component Test Code*Component Chart Name
0020606Zinc Protoporphyrin - Ratio to Hgb
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Cross References
  • Porphyrins
  • ZP
  • ZPP
  • ZPP/Heme Ratio