Zinc Protoporphyrin (ZPP), Whole Blood
Ordering Recommendation

Useful as an indicator of chronic exposure to lead, primarily in the industrial setting. For iron deficiency assessment, Iron and Iron Binding Capacity (0020420) and Ferritin (0070065) are recommended. For lead exposure assessment, Lead Blood (Venous) (0020098) is preferred. For occupational exposure to lead assessment, Zinc Protoporphyrin (ZPP) Whole Blood Industrial (0020614) or Lead Industrial Exposure Panel, Adults (0025016) are recommended.

Quantitative Hematofluorometry
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Lavender (EDTA); Royal blue, (EDTA), tan (EDTA), or pink (K2 EDTA). Use royal blue (EDTA) tube when also testing for lead. 
Specimen Preparation
Transport 1 mL whole blood. (Min: 0.2 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Specimens not collected in EDTA. Clotted, frozen, or hemolyzed specimens. 
Ambient: 30 hours; Refrigerated: 5 weeks; Frozen: Unacceptable 
Reference Interval
0-69 µmol ZPP/ mol Hem
Interpretive Data

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria.  Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.

A more specific test for free protoporphyrin is Porphyrins, Serum Total (0080429).  Erythrocyte Porphyrin (EP), Whole Blood (0020610), measures free protoporphyrin and zinc protoporphyrin.
Hotline History
Component Test Code*Component Chart NameLOINC
0020606Zinc Protoporphyrin (ZPP) WholeBld Ratio29763-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Porphyrins
  • ZP
  • ZPP
  • ZPP/Heme Ratio