Copper, Serum Free (Direct)
0020596
Ordering Recommendation
Submit With Order
Mnemonic
COPPER F
Methodology
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Performed
Tue, Thu, Sat
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).  
Collect
Royal blue (no additive).  
Specimen Preparation
Centrifuge. Transfer 2.5 mL serum to an ARUP Trace Element-Free Transport Tube. (Min: 1.5 mL) Do not allow serum to remain on cells.  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Separator tubes. Specimens that are not separated from the red cells or clot.  
Remarks
 
Stability
After separation from cells: Ambient: 8 hours; Refrigerated: 1 week; Frozen: 1 month  
Reference Interval
0.0-10.0 µg/dL
Interpretive Data
Free copper (direct) is determined with serum ultrafiltrate. Results may be elevated in Wilson disease or other conditions of copper overload. Other tests used to diagnosis Wilson disease include serum ceruloplasmin, 24-hour urine copper, and hepatic copper. Slit lamp examination for Kayser-Fleischer rings and genetic testing may also be helpful.

See Compliance Statement B: www.aruplab.com/CS
Note
Elevated results from noncertified trace element-free tubes may be due to contamination. Elevated concentrations of trace elements in serum should be confirmed with a second specimen collected in a trace element-free tube, such as royal blue sterile tube (no additive).
CPT Code(s)
82525
Components
Component Test Code*Component Chart Name
0020596Copper, Serum Free (Direct)
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • Copper Index
  • Cu
  • Cu, Plasma
  • CuFree
  • Free copper
  • Non-Ceruloplasmin Bound Copper
  • Unbound Copper