Creatine Kinase Isoenzymes
0020414
Ordering Recommendation
Aids in determining the etiology of elevated total creatine kinase. Cardiac troponins [troponin I (0090613) or troponin T (0098803)] are the recommended tests for diagnosis and management of acute coronary syndrome. May aid in identifying the presence of macro creatine kinase.
Mnemonic
CKISO
Methodology
Quantitative Enzymatic/Electrophoresis
Performed
Sun-Sat
Reported
Between 2 and 3 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube or plain red.  
Specimen Preparation
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Specimens preserved in citrate, EDTA, fluoride, heparin, or iodoacetate. Room temperature specimens.  
Remarks
This test will detect CK macroenzymes.  
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)  
Reference Interval
 
 
Test Number Components Reference Interval
 CK-​MM96-​100%
 CK-​MB 0-​4%
 CK-​BB 0%
 CK-​Macro Type I 0%
 CK-​Macro Type II 0%
 Creatine Kinase, Total  
 
Age: Male: Female:
0-​19 years:
20 years and older:
By report
20-​200 U/L
By report
20-​180 U/L
Interpretive Data
 
Note
CK-MB and CK-BB are quite labile; freeze specimen if the test cannot be performed within 24 hours.
CPT Code(s)
82552; 82550
Components
Component Test Code*Component Chart NameLOINC
0020020CK-MM15049-0
0020021CK-MB12187-1
0020022CK-BB15048-2
0020108CK Total2157-6
2001881CK-Macro Type I26019-0
2001882CK-Macro Type II26020-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CK
  • CK Isoenzyme Electrophoresis
  • CK Isoenzymes
  • CK Macro
  • CK-BB
  • CK-MM
  • CKBB
  • CKMB
  • CPK
  • CPK Isoenzyme Electrophoresis
  • CPK Isoenzymes (Creatine Phosphokinase Isoenzymes)
  • Creatine Phosphokinase
  • Isoenzyme of Creatine Kinase
  • Isoenzymes, CK
  • Macro CK
  • Macro Creatine Kinase
  • Mitochondrial C