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LDL Cholesterol, Direct
0020257
Ordering Recommendation
Mnemonic
LDL D
Methodology
Quantitative Detergent Solubilization/ Enzymatic
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Plasma separator tube or serum separator tube. Also acceptable: Green (sodium or lithium heparin), lavender (EDTA), or pink (K2EDTA). 
Specimen Preparation
Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
 
Remarks
 
Stability
After separation from cells: Ambient: 8 hours; Refrigerated: 5 days; Frozen: 1 month 
Reference Interval
Age
Desirable
Borderline
Higher Risk
0-19 years109 mg/dL or less110-129 mg/dL130 mg/dL or greater
20 years and older129 mg/dL or less (99 mg/dL or less if patient has CHD)130-159 mg/dL160 mg/dL or greater

Interpretive Data
CHD Risk Factors:
+1 Age: Men, 45 years and older
Women, 55 years and older or premature menopause without estrogen therapy
+1 Family history of premature CHD
+1 Current smoking
+1 Hypertension
+1 Diabetes mellitus
+1 Low HDL Cholesterol: 39 mg/dL or less
-1 High HDL Cholesterol: 60 mg/dL or greater

LDL Cholesterol: Therapeutic goal
99 mg/dL or less if CHD is present (Optional 69 mg/dL or less).
129 mg/dL or less if no CHD and two or more risk factors.
159 mg/dL or less if no CHD.
(Circulation 2004; 110:227-39)

Note
CPT Code(s)
83721
Components
Component Test Code*Component Chart NameLOINC
0020257LDL Cholesterol, Direct2089-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Direct LDL
  • LDL
  • Low Density Lipoprotein