Differential evaluation of encephalitis of unknown origin with subacute onset of seizures, confusion, memory loss, and/or behavioral change. Detect antibodies in addition to those included in Autoimmune Encephalitis Reflexive Panel (2013601). Testing for LGI1 and CASPR2 antibodies is always performed rather than only as a reflex. For adults and patients with suspicion of cancer, additional evaluation of paraneoplastic autoantibodies is recommended; refer to Paraneoplastic Reflexive Panel (2013955).
- Patient Preparation
- Serum Separator Tube (SST).
- Specimen Preparation
- Separate from cells ASAP or within 2 hours of collection. Transfer three (3) 1 mL serum aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)
- Storage/Transport Temperature
- Unacceptable Conditions
- Contaminated specimens.
- After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)
|Test Number||Components||Reference Interval|
|2004221||N-methyl-D-Aspartate Receptor Antibody, IgG, Serum with Reflex to Titer||< 1:10|
|2001771||Glutamic Acid Decarboxylase Antibody||0.0-5.0 IU/mL|
|2004890||Voltage-Gated Potassium Channel (VGKC) Antibody, Serum|
|2003036||Aquaporin-4 Receptor Antibody||Effective October 3, 2016|
|2013320||Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum||Less than 1:10|
|2009456||Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer||Less than 1:10|
|2009452||Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer||Less than 1:10|
|3001260||Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, Serum||Less than 1:10|
|3001270||Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, Serum||Less than 1:10|
|3001277||Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum||Less than 1:10|
If Aquaporin-4 Receptor Antibody IgG by ELISA is positive, then Aquaporin-4 Receptor Antibody, IgG by IFA will be added. If positive, then a titer will be added. Additional charges apply.
If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. Additional charges apply.
If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
If AMPAR Antibody IgG is positive, then a titer will be added. Additional charges apply.
If GABABR Antibody IgG is positive, then a titer will be added. Additional charges apply.
If MOG Antibody IgG is positive, then a titer will be added. Additional charges apply.
83516, if reflexed add 86255, if further reflexed add 82656;
86255 x6, if reflexed add 82656 per titer
|Component Test Code*||Component Chart Name||LOINC|
|2001772||Glutamic Acid Decarboxylase Antibody||56540-8|
|2003121||Aquaporin-4 Receptor Antibody||61430-5|
|2004222||N-methyl-D-Aspartate Receptor Ab, Serum||80221-5|
|2004890||Voltage-Gated Potassium Channel Ab, Ser||41871-5|
|2009453||CASPR2 Ab IgG Screen by IFA||82979-6|
|2009457||LGI1 Ab IgG Screen by IFA||82978-8|
|3001261||AMPA Receptor Ab IgG Screen, Serum||82733-7|
|3001271||GABA-B Receptor Ab IgG Screen, Serum||82977-0|
|3001278||MOG Antibody IgG Screen, Serum|