Autoimmune Encephalitis Extended Panel
3001431
Ordering Recommendation

Differential evaluation of encephalitis of unknown origin with subacute onset of seizures, confusion, memory loss, and/or behavioral change. Detect antibodies in addition to those included in Autoimmune Encephalitis Reflexive Panel (2013601). Testing for LGI1 and CASPR2 antibodies is always performed rather than only as a reflex. For adults and patients with suspicion of cancer, additional evaluation of paraneoplastic autoantibodies is recommended; refer to Paraneoplastic Reflexive Panel (2013955).

Mnemonic
ENCEPH EXT
Methodology
Semi-Quantitative Indirect Fluorescent Antibody/Quantitative Radioimmunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
3-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum Separator Tube (SST). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer three (3) 1 mL serum aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Contaminated specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles) 
Reference Interval
Test Number
Components
Reference Interval
2004221N-methyl-D-Aspartate Receptor Antibody, IgG, Serum with Reflex to Titer< 1:10
2001771Glutamic Acid Decarboxylase Antibody0.0-5.0 IU/mL
2004890Voltage-Gated Potassium Channel (VGKC) Antibody, Serum
Negative31 pmol/L or less
Indeterminate32-87 pmol/L
Positive88 pmol/L or greater

2003036Aquaporin-4 Receptor AntibodyEffective October 3, 2016
Negative2.9 U/mL or less
Positive3.0 U/mL or greater

2013320Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, SerumLess than 1:10
2009456Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to TiterLess than 1:10
2009452Contactin-Associated Protein-2 Antibody, IgG with Reflex to TiterLess than 1:10
3001260Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, SerumLess than 1:10
3001270Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, SerumLess than 1:10
3001277Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, SerumLess than 1:10

Interpretive Data
Refer to report.

Statement D: Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
If N-methyl-D-Aspartate Receptor Antibody is positive, then a titer will be added. Additional charges apply.
If Aquaporin-4 Receptor Antibody IgG by ELISA is positive, then Aquaporin-4 Receptor Antibody, IgG by IFA will be added. If positive, then a titer will be added. Additional charges apply.
If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. Additional charges apply.
If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
If AMPAR Antibody IgG is positive, then a titer will be added. Additional charges apply.
If GABABR Antibody IgG is positive, then a titer will be added. Additional charges apply.
If MOG Antibody IgG is positive, then a titer will be added. Additional charges apply.
Hotline History
View Hotline History
CPT Code(s)
83519; 86341;
83516, if reflexed add 86255, if further reflexed add 82656;
86255 x6, if reflexed add 82656 per titer
Components
Component Test Code*Component Chart NameLOINC
2001772Glutamic Acid Decarboxylase Antibody56540-8
2003121Aquaporin-4 Receptor Antibody61430-5
2004222N-methyl-D-Aspartate Receptor Ab, Serum80221-5
2004890Voltage-Gated Potassium Channel Ab, Ser41871-5
2009453CASPR2 Ab IgG Screen by IFA82979-6
2009457LGI1 Ab IgG Screen by IFA82978-8
3001261AMPA Receptor Ab IgG Screen, Serum82733-7
3001271GABA-B Receptor Ab IgG Screen, Serum82977-0
3001278MOG Antibody IgG Screen, Serum
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at www.aruplab.com
Aliases