Desipramine, Serum or Plasma by Tandem Mass Spectrometry
2011487
Ordering Recommendation

Optimize drug therapy and monitor patient adherence. Test only measures desipramine concentration. If imipramine will be administered, order Imipramine and Desipramine, Serum or Plasma (0090157).

Mnemonic
DESIPRAMIN
Methodology
Quantitative Liquid Chromatography/Tandem Mass Spectrometry
Performed
Mon, Wed, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum Pre-dose (Trough) Draw - At a Steady State Concentration or Plasma Pre-dose (Trough) Draw - At a Steady State Concentration in Plain Red, Lavender (K2EDTA), Lavender (K3EDTA), or Pink (K2EDTA). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Whole blood. Gel Separator Tubes, Light Blue (Sodium Citrate), or Yellow (SPS or ACD Solution). 
Remarks
 
Stability
Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months 
Reference Interval
Therapeutic Range:100-300 ng/mL
Toxic:Greater than 500 ng/mL

Interpretive Data
The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Toxic concentrations may cause anticholinergic effects, drowsiness and cardiac abnormalities.

Statement B: Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
View Hotline History
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
2011491Desipramine Serum or Plasma3531-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at www.aruplab.com
Aliases
  • Norpramin
  • Pertofrane
  • TCA
  • Tricyclic Antidepressants