Parathyroid Hormone-Related Peptide (PTHrP) by LC-MS/MS, Plasma
Ordering Recommendation

Aid in the evaluation of unexplained hypercalcemia, particularly in suspected hypercalcemia of malignancy. Amino (N)- and carboxy (C)-terminus PTHrP fragments, such as those produced by some patients with renal insufficiency, do not interfere with this assay.

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Sun, Mon, Wed, Fri
2-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Protease Inhibitor tube (PPACK; Phe-Pro-Arg-chloromethylketone)  (ARUP supply #49662), available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.  A winged collection set must be used. 
Specimen Preparation
Mix well. Separate from cells within 1 hour of collection. Transfer 1.5 mL plasma to an ARUP Standard Transport Tube. (Min: 0.7 mL) 
Storage/Transport Temperature
Frozen. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Grossly hemolyzed specimens. 
After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 3 months 
Reference Interval
Effective August 17, 2015
Under 18 yearsNot establishedNot established
18 years and older0.0-2.3 pmol/L0.0-3.4 pmol/L

Interpretive Data

Statement B: Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Amino (N)- and carboxy (C)-terminus PTHrP fragments, such as those produced by some patients with renal insufficiency, do not interfere with this assay.
Hotline History
Component Test Code*Component Chart NameLOINC
0093016PTHrP by LC-MS/MS, Plasma15087-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at
  • HHM
  • Humoral Hypercalcemia of Malignancy Factor
  • Parathyroid Hormone Related Peptide
  • Parathyroid Hormone Related Protein
  • Parathyroid Related Polypeptide
  • Parathyroid Related Protein
  • PRP
  • PTH Related Peptide
  • PTH Related Protein
  • PTH-RP
  • PTHrP secretion
  • PTHRP, Plasma