Lung Cancer Panel with KRAS
Ordering Recommendation

Screening panel detects EGFR and KRAS mutations (pyrosequencing), ALK and ROS1 fusion proteins (IHC).

Polymerase Chain Reaction/Pyrosequencing/Immunohistochemistry
7-14 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Tumor tissue. 
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block or 13 unstained 5- micron slides (8 on positively charged slides AND 5 on uncharged slides). (Min: 9 slides: 5 positively charged AND 4 uncharged). Tissue block will be returned after testing. Transport block and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787 
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months. 
Unacceptable Conditions
Less than 25 percent tumor. Specimens fixed/processed in alternative fixatives (alcohol, Prefer®) or heavy metal fixatives. Decalcified specimens. 
Include surgical pathology report. 
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable 
Reference Interval
Interpretive Data
Refer to report.

Statement B: Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Panel consists of KRAS Mutation Detection by Pyrosequencing, EGFR Mutation Detection by Pyrosequencing, ALK (D5F3) with Interpretation by Immunohistochemistry, and ROS1 with Interpretation by Immunohistochemistry with Reflex to FISH if Equivocal. If reflexed, additional charges apply.
Hotline History
View Hotline History
CPT Code(s)
88381; 81275; 81276; 81235; 88342; 88341; if reflexed, add 88366
Component Test Code*Component Chart NameLOINC
0040249KRAS Mutation Detection21702-6
2002148Block ID57723-9
2002442EGFR by Pyrosequencing21665-5
2007325ALK(D5F3) by IHC Reference Number57723-9
2007327ALK(D5F3) by IHC Result35474-6
2008415ROS1 by IHC Result
2008417ROS1 Client Block ID
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at