Use to test amniotic fluid for the following indications:
Abnormal US findings
Abnormal prenatal screen
Genomic microarray testing is performed on normal chromosome analysis results. In cases with a normal karyotype, microarray studies reveal clinically relevant copy number variations (CNV) in ~6% of fetuses with an ultrasound anomaly and ~2% whose indication is advanced maternal age or positive aneuploidy screen.
If reflexed: 7-10 additional days required for microarray
- Patient Preparation
- Amniotic fluid.
- Specimen Preparation
- Do not freeze or expose to extreme temperatures. Transport 15-30 mL amniotic fluid in a sterile container.
- Storage/Transport Temperature
- Room temperature.
- Unacceptable Conditions
- Ambient: 48 hours; Refrigerated: 48 hours Frozen: Unacceptable
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Maternal cell contamination studies recommended if testing reflexes to the fetal microarray. For maternal cell contamination studies if testing reflexes to the fetal microarray, please submit a maternal blood sample and order Microarray Genomic, Maternal Confirm (ARUP test code 2002369) accompanied by a test request form for the mother (this test is performed at no charge as part of the fetal microarray). Maternal blood should be submitted along with the amniotic fluid sample at the time the test ordered. For questions regarding ordering please contact ARUP's genetic counselor at (800) 242-2787 ext. 2141.
The chromosome analysis studies involve culturing of living cells; therefore, turnaround times given represent average times which are subject to multiple variables. After specimen receipt, results are generally available in an average of 12 days with 7-10 additional days required for microarray.
A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth
This test must be ordered using Cytogenetic test request form 43098 or through your ARUP interface. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (http://ltd.aruplab.com/Tests/Pdf/65). Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.
|Component Test Code*||Component Chart Name||LOINC|
|0097601||Chromosome Analysis, Amniotic Fluid||33773-3|
|2009476||EER Chrom Analysis AF w/Rflx to Array|
- Amniotic Fluid, Chromosome Analysis
- Array CGH, Prenatal
- comparative genomic hybridization, prenatal
- Karyotype, Amniotic Fluid
- Prenatal array
- Prenatal Chromosomes, Amniotic Fluid
- Prenatal Diagnosis