Leukocyte Adhesion Deficiency Panel
Ordering Recommendation

Aids in the diagnosis of type I and II leukocyte adhesion deficiency. Panel measures CD11b, CD15, and CD18 on neutrophils.

Semi-Quantitative Flow Cytometry
1-3 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Green (sodium or lithium heparin). 
Specimen Preparation
Transport 5 mL whole blood. (Min: 1 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Clotted specimens. Frozen or room temperature specimens.  Specimens greater than 48 hours. 
Client must supply a CBC and a differential with the whole blood specimen. The differential must include eosinophil and basophil counts. Specimen must be analyzed within 48 hours of collection. 
Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: Unacceptable 
Reference Interval
Effective August 20, 2012
Available Separately
Reference Interval
No%  CD11b93-100%
No%  CD1591-100%
No%  CD1898-100%

Interpretive Data
The Leukocyte Adhesion Deficiency Panel measures the receptors CD11b, CD15, and CD18 on neutrophils. The percentage of patient neutrophils bearing these receptors is reported. Although these receptors are normally found on neutrophils; values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD18 is decreased or absent in Leukocyte Adhesion Deficiency (LAD) type I and CD15 is decreased or absent in LAD type II.

Statement A: Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Hotline History
Component Test Code*Component Chart NameLOINC
0095818% CD1838170-7
0095922% CD11b17110-8
0095957% CD1520590-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at www.aruplab.com
  • Beta 2 integrins
  • CD11b; CD15; CD18
  • LAD I, II determination