Human Epididymis Protein 4 (HE4)
2003020
Ordering Recommendation

Use with CA 125 to monitor ovarian cancer, usually epithelial subtype, post therapy if pretreatment level was elevated. Not recommended for monitoring known mucinous or germ cell ovarian cancer. Not a stand-alone test for ovarian cancer screening or diagnosis.

Mnemonic
HE4
Methodology
Quantitative Electrochemiluminescent Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum Separator Tube (SST). Also acceptable: Green (Lithium Heparin), Lavender (K2 EDTA), or Lavender (K3 EDTA). 
Specimen Preparation
Allow specimen to clot completely at room temperature. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Grossly hemolyzed specimens. 
Remarks
 
Stability
Ambient: 5 hours; Refrigerated: 48 hours; Frozen: 4 months 
Reference Interval
0-140 pmol/L
Interpretive Data
Human Epididymis Protein 4 (HE4) is to be used as an aid in monitoring recurrence or progressive disease in patients with epithelial ovarian cancer. Serial testing for patient HE4 assay values should be used in conjunction with other clinical findings for monitoring ovarian cancer. ARUP uses the Roche Cobas e602 electrochemiluminescent assay. Values obtained with different assay methods should not be used interchangeably.

Note
Hotline History
N/A
Components
Component Test Code*Component Chart NameLOINC
2003021Human Epididymis Prot 455180-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at www.aruplab.com
Aliases
  • HE 4
  • HE4
  • Human HE4 Antigen