ST2, Soluble
Ordering Recommendation

B-Type Natriuretic Peptide (0030191) or proBrain Natriuretic Peptide, NT (0050083) are preferred tests for diagnosis, prognosis, and management of acute and chronic heart failure. ST2 aids in prognostication in patients with acute and chronic heart failure.

Quantitative Enzyme Immunoassay
Tue, Fri
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum Separator Tube (SST), Plain Red, Lavender (EDTA), Pink (K2EDTA), or Green (Sodium or Lithium Heparin). 
Specimen Preparation
Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transport 1 mL serum or plasma in an ARUP Standard Transport Tube. (Min: 0.2 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Citrated plasma. Grossly hemolyzed or severely lipemic specimens. 
After separation from cells: Ambient: 48 hours; Refrigerated: 10 days; Frozen: 18 months 
Reference Interval
Males10.4-52.1 ng/mL
Females8.4-33.6 ng/mL

Interpretive Data
The Presage ST2 test is an enzyme-linked immunosorbent assay that quantifies soluble ST2 in serum or plasma. ST2 is a member of the interleukin-1 (IL-1) receptor family and is secreted by cardiac muscle cells under conditions of mechanical stress. In individuals with acute myocardial infarction, an increased concentration of soluble ST2 is associated with an increased risk of mortality or heart failure. In individuals with heart failure, an increased concentration of soluble ST2 is strongly associated with the severity of disease, and is a strong predictive indicator of a 1-year mortality that is independent from but additive to that of NT-proBNP.

Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
2002268ST2, Soluble55927-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at
  • ST2