Voriconazole, Quantitation by LC-MS/MS
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
1-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Specimens collected just before or within 15 minutes of the next dose represent the TROUGH levels. Specimens obtained within 15-30 minutes after the end of I.V. infusion or 45-60 minutes after an IM injection or 90 minutes after oral intake represent the PEAK level. Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.6 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Separator tubes. Hemolyzed or lipemic specimens. 
After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months 
Reference Interval
Effective February 19, 2013
Therapeutic Range (trough)1.0-6.0  µg/mL
Toxic LevelGreater than 6.0 µg/mL

Interpretive Data
Toxic concentrations may cause nausea, vomiting, peripheral edema and elevated serum liver enzymes.

Statement B: Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
Component Test Code*Component Chart NameLOINC
2001738Voriconazole, Quantitation by LC-MS/MS38370-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at www.aruplab.com
  • Vfend
  • Vfend blood concentration
  • voriconazole blood concentration