Nickel, Serum
Ordering Recommendation

Serum nickel may be informative in the investigation of toxic exposure. Nickel, Urine (0025045) is the preferred test for the determination of exposure. Measurement of nickel is not recommended in asymptomatic individuals or individuals with a low likelihood of exposure.

Quantitative Inductively Coupled Plasma-Mass Spectrometry
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). 
Royal Blue (no additive). 
Specimen Preparation
Centrifuge; do not allow serum to remain on cells. Transfer 2 mL serum to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116) within 2 hours of collection. Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL) 
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated or frozen. 
Unacceptable Conditions
Specimens collected in tubes other than Royal Blue (no additive). Specimens transported in containers other than a Royal Blue (no additive) tube or Trace Element-Free Transport Tube. Heparin anticoagulant. Specimens that are not separated from the red cells or clot within 2 hours. 
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely 
Reference Interval
Less than or equal to 10.0 µg/L
Interpretive Data
Elevated results may be due to skin or collection-related contamination, including the use of a noncertified metal-free collection/transport tube. If contamination concerns exist due to elevated levels of serum nickel, confirmation with a second specimen collected in a certified metal-free tube is recommended.

Serum nickel testing is intended to detect potentially toxic exposure.

Statement B: Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
0099452Nickel, Serum5702-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at
  • Ni
  • Nickel serum level
  • NIS