Thyroid Stimulating Immunoglobulin
Ordering Recommendation

Acceptable test for autoimmune thyroid disease.

Semi-Quantitative Bioassay/Quantitative Chemiluminescent Immunoassay
2-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Plain red or serum separator tube. 
Specimen Preparation
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.7 mL) 
Storage/Transport Temperature
Unacceptable Conditions
After separation from cells: Ambient: 24 hours; Refrigerated: 6 days; Frozen: 3 months 
Reference Interval
Effective August 20, 2012
Negative122% basal activity or less
Positive123% basal activity or greater

Interpretive Data
Positive results (123 percent or greater) are consistent with Graves disease but do not always correlate with the presence and severity of hyperthyroidism. Antibodies to the Thyroid Stimulating Hormone Receptor (TSHR) may be stimulating, blocking, or neutral. Stimulating antibodies mimic the action of TSH and cause hyperthyroidism (Graves disease). This test determines the net effect of all TSHR antibody types present in the serum specimen.

Statement B: Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

An elevated Thyroid Stimulating Hormone (TSH) value above 6 mU/L may produce a weakly positive Thyroid Stimulating Immunoglobulin (TSI) result (123 percent or greater).
Hotline History
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Component Test Code*Component Chart NameLOINC
0099430Thyroid Stimulating Immunoglobulin30166-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at
  • Autoimmune Thyroid Stimulator
  • Thyroid Stimulating Antibody
  • Thyroid-Stimulating Immunoglobulin Serum
  • TSI
  • TSI concentration