Manganese, Serum
Ordering Recommendation

May be useful as a reasonable indicator of recent, active exposure and provides a modest indicator for distinguishing exposed from nonexposed individuals. Not recommended for the assessment of manganese body stores. Manganese, Whole Blood (0099272) is recommended for monitoring potential accumulation with TPN.

Quantitative Inductively Coupled Plasma-Mass Spectrometry
Mon, Wed, Fri
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter
medications (upon the advice of their physician). 
Royal blue (no additive). 
Specimen Preparation
Do not allow serum to remain on cells. Centrifuge and pour off serum. Transfer 2 mL serum to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL) 
Storage/Transport Temperature
Room temperature. 
Unacceptable Conditions
Separator tubes. Specimens that are not separated from the red cells, or clot, within 6 hours. Hemolyzed specimens. 
If the specimen is drawn and stored in the appropriate container, the trace element values do not change with time. 
Reference Interval
0.0-2.0 µg/L
Interpretive Data
Less than 5% of manganese present in circulation resides in the serum.

Statement B: Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Elevated results from noncertified trace element-free tubes may be due to contamination.  Elevated concentrations of trace elements in serum should be confirmed with a second specimen collected in a trace element-free tube, such as a royal blue sterile tube (no additives).
Hotline History
Component Test Code*Component Chart NameLOINC
0099265Manganese, Serum5683-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at
  • Mn
  • Mn blood level
  • MNS
  • Serum manganese concentration