Oligoclonal Bands in CSF and Serum
Ordering Recommendation

Use for assessment of multiple sclerosis. Detect unique IgG oligoclonal bands in cerebrospinal fluid (CSF) in conjunction with a matched serum specimen. Preferred test is Oligoclonal Band Profile (0080440).

Qualitative Isoelectric Focusing/Electrophoresis
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
CSF AND serum separator tube or plain red. Serum specimen should be drawn within 48 hours of CSF collection. 
Specimen Preparation
Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transport 1.5 mL CSF (Min: 0.7 mL) AND transfer 1 mL serum to an ARUP Standard Transport Tube (Min: 0.5 mL). 
Storage/Transport Temperature
Unacceptable Conditions
Ambient: 8 hours; Refrigerated: 1 week; Frozen: 1 year 
Reference Interval
Effective August 6, 2012
Test Number
Reference Interval
0081139Oligoclonal Bands, CSFNegative
2005461Oligoclonal Bands Number, CSF0 - 1 Bands
InterpretationBy report

Interpretive Data

Specimens must be assayed together for interpretation.
This test reports only the number of oligoclonal bands.  A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.
Hotline History
Component Test Code*Component Chart NameLOINC
0081139Oligoclonal Bands, CSF48668-8
2005461Oligoclonal Bands Number, CSF49852-7
2005464Oligoclonal Bands Interpretation49293-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at www.aruplab.com
  • CSF oligoclonal bands
  • Oligoclonal Bands Only
  • Oligoclonal IgG, CSF
  • Oliogoclonal bands, CSF