Vitamin A (Retinol), Serum or Plasma
Ordering Recommendation

Use for nutritional assessment of vitamin A (retinol and retinyl palmitate) in serum or plasma.

Quantitative High Performance Liquid Chromatography
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Patient should fast for 12 hours and abstain from alcohol for 24 hours prior to collection. 
Green (sodium or lithium heparin), plasma separator tube, or serum separator tube. Also acceptable: Lavender (EDTA) or pink (K2EDTA). 
Specimen Preparation
Separate serum or plasma within 1 hour of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube immediately. (Min: 0.2 mL) Avoid hemolysis. 
Storage/Transport Temperature
Unacceptable Conditions
Whole blood or body fluids other than serum or plasma. 
After separation from cells: Ambient: Unacceptable; Refrigerated: 1 month; Frozen: 1 year 
Reference Interval
Test Number
Reference Interval
 Vitamin A (Retinol)
Reference Interval
0-1 month
2 months-12 years
13-17 years
18 years and older
0.18-0.50 mg/L
0.20-0.50 mg/L
0.26-0.70 mg/L
0.30-1.20 mg/L

 Vitamin A (Retinyl Palmitate)0-150 years: 0-0.10 mg/L

Interpretive Data

Statement B: Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Serum retinol is typically maintained until hepatic stores are almost depleted. Values greater than 0.30 mg/L represent adequate liver stores, whereas values less than 0.10 mg/L indicate deficiency. Samples that come in contact with plastic tubing or have been exposed to excessive light may show low results.

Vitamin A toxicity occurs when retinol concentration exceeds the capacity of retinol binding protein (RBP). Individuals with compromised renal function can retain RBP and may, therefore, have moderate retinol elevations. Drugs which interfere with vitamin A analysis include probucol (Lorelco).

This assay does not measure other vitamin A metabolites such as retinaldehyde and retinoic acid.
Hotline History
Component Test Code*Component Chart NameLOINC
0080375Vitamin A (Retinol)2923-1
0080523Vitamin A, Ser/Pla - Interpretation48767-8
0080524Vitamin A (Retinyl Palmitate)38496-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at
  • A Vitamin
  • Retinol
  • Retinyl palmitate