Epstein-Barr Virus Antibody to Early D Antigen (EA-D), IgG
Ordering Recommendation

May aid in the diagnosis of acute Epstein-Barr virus (EBV) infection and EBV reactivation in conjunction with other serologic studies. Molecular tests are preferred to detect EBV reactivation. Not a stand-alone test.

Semi-Quantitative Chemiluminescent Immunoassay
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum Separator Tube (SST). 
Specimen Preparation
Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. 
Storage/Transport Temperature
Unacceptable Conditions
Contaminated,  heat-inactivated or grossly hemolyzed specimens. 
Label specimens plainly as "acute" or "convalescent." 
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Effective February 19, 2013

8.9 U/mL or less: Not Detected
9.0-10.9 U/mL: Indeterminate - Repeat testing in 10-14 days may be helpful.
11.0 U/mL or greater: Detected
Interpretive Data
Interpretive information regarding serologic features of EBV-associated diseases is available at www.arupconsult.com/ebvdx .

EBV EA-D values obtained with different manufacturers' assay methods may not be used interchangeably.  The magnitude of the reported EBV EA-D level cannot be correlated to an endpoint titer.
Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
0050225EBV Antibody to Early (D) Antigen IgG50969-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at www.aruplab.com
  • EA-D IgG Ab
  • EAD Ab
  • EBNA Antibody
  • EBNA to EA-D
  • EBV Antibody to Early D Antigen
  • EBV Nuclear Antibody