Lupus Comprehensive Reflexive Panel
Ordering Recommendation

Recommended for the evaluation of systemic lupus erythematosus (SLE).

Quantitative Immunoturbidimetry/Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Quantitative Chemiluminescent Immunoassay/Semi-Quantitative Multiplex Bead Assay
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube. 
Specimen Preparation
Allow specimen to clot for 30 to 60 minutes at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 4 mL serum to an ARUP Standard Transport Tube and freeze immediately. (Min: 2 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Plasma. Specimens left to clot while refrigerated. Contaminated, hemolyzed, or severely lipemic specimens. 
After separation from cells: Ambient: 1 hour; Refrigerated: 24 hours, Frozen: 2 weeks 
Reference Interval
By report
Interpretive Data

Initial testing includes RF, C3, C4, and ANA. Specimens are screened for ANA using ELISA. If antibodies are detected, then an IFA titer will be added. If confirmed by IFA, then specimen will be tested for Thyroid Peroxidase (TPO) Antibody; Anti-Scl-70 (ENA), EIA; Smith/RNP (ENA) Antibody, IgG; Smith (ENA) Antibody, IgG; SSA 52 and 60 (Ro) (ENA) Antibodies, IgG; SSB (La) (ENA) Antibody, IgG; and Double-Stranded DNA (dsDNA) Antibody, IgG by ELISA; if Double-Stranded DNA (dsDNA) Antibody, IgG by ELISA result is Detected, then Double-Stranded DNA (dsDNA) Antibody, IgG by IFA (using Crithidia luciliae) is added. Additional charges apply.
Hotline History
View Hotline History
CPT Code(s)
86431; 86160 x2; 86038; if reflexed, add 86039; if reflexed, add 86235 x6; 86376; 86225; if reflexed, add 86256
Component Test Code*Component Chart NameLOINC
0050080Anti-Nuclear Ab (ANA), IgG by ELISA29950-3
0050150Complement Component 34485-9
0050155Complement Component 44498-2
0050465Rheumatoid Factor11572-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at
  • ANA IgG
  • Anti-Nuclear Ab (ANA), IgG
  • Complement C3
  • Complement C4
  • Complement Component 3
  • Complement Component 4
  • Lupus Panel
  • Lupus Reflex Panel
  • RA factor
  • RF
  • Rheumatoid Factor