Assess risk of progression to severe sepsis and septic shock in critically ill patients upon admission to ICU. Use in conjunction with other laboratory findings.
- Patient Preparation
- The same specimen type (serum, plasma) should be used throughout the patient's clinical course.
- Plasma Separator Tube (PST) or Serum Separator Tube (SST).
- Specimen Preparation
- Allow serum to sit for 15-20 minutes for proper clot formation and to ensure the absence of fibrin in the serum which can interfere with this assay. Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL)
- Storage/Transport Temperature
- Unacceptable Conditions
- Specimens collected in citrate anticoagulant.
- After separation from cells: Ambient: 24 hours; Refrigerated: 5 days; Frozen: 15 days
Procalcitonin > 2.00 ng/mL: Procalcitonin levels above 2.00 ng/mL on the first day of ICU admission represent a high risk for progression to severe sepsis and/or septic shock.
Procalcitonin < 0.50 ng/mL: Procalcitonin levels below 0.50 ng/mL on the first day of ICU admission represent a low risk for progression to severe sepsis and/or septic shock.
If the procalcitonin measurement is performed shortly after the systemic infection process has started (usually less than 6 hours), these values may still be low. As various non-infectious conditions are known to induce procalcitonin as well, procalcitonin levels between 0.50 ng/mL and 2.00 ng/mL should be reviewed carefully to take into account the specific clinical background and condition(s) of the individual patient.
|Component Test Code*||Component Chart Name||LOINC|
- antibiotic adequacy
- Procalcitonin Sepsis Biomarker